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1 Introduction

Over the last two decades, computer modeling and simulation have become increasingly important to the fields of Bioengineering and Medicine. The reasons for this growing importance are manyfold. First, mathematical modeling has been shown to be a substantial tool for the investigation of complex biophysical phenomena. Secondly, since the level of complexity one can model parallels existing hardware configurations, primarily tuned to memory, disk capacity, and CPU speed advances in computer technology have made it feasible to apply the computational modeling paradigm to complex living systems.

For these reasons, biological complexity still outstrips the capabilities of even the largest computational systems, and will for some time to come, the computational methodology has taken hold in biology and medicine and has been used successfully to suggest physiologically and clinically important scenarios and results.