Oak Ridge National Laboratory

Physics Division

Physics Division Seminars

Physics Division Seminars bring us speakers on a variety of physics related subjects. Usually these are held in the Building 6008 large Conference Room, at 3:00 pm on the chosen day, but times and locations may vary. For more information, contact our seminar chairman,

Alfredo Galindo-Uribarri
Tel (Office): (865) 574-6124  (FAX): (865) 574-1268

Tue., October 25, 2016, at 3:00 PM - 4:00 PM (refreshments served at 2:40 PM)

Production of Radionuclides with Accelerators Big and Small: Complementary Techniques for Filling the Toolbox of Useful Radiotracers

Prof. Suzanne Lapi, Dept. Radiology, University of Alabama at Birmingham
Bldg. 6008 Large Conference Room

The increase in use of radioisotopes for medical imaging and therapy has led to the development of new accelerator targetry and separation techniques for isotope production. For example, the production and purification of longer-lived positron emitting radionuclides has been explored to allow for nuclear imaging agents based on peptides, antibodies, and nanoparticles. These isotopes (64Cu, 89Zr, 86Y) are typically produced via irradiation of solid targets on smaller medical cyclotrons (<25 MeV) at academic or hospital based facilities. Additionally, recent research has further expanded the toolbox of PET tracers to include additional isotopes such as 52Mn, 55Co and others. The small scale of these types of facilities can enable the involvement of undergraduate and graduate students for a variety of projects. Research pertaining to development of robust and larger scale production technologies including solid target systems and remote systems for transport and purification of these isotopes has enabled both preclinical and clinical imaging research for many diseases.

More recently, alternative techniques such as isotope harvesting via heavy-ion fragmentation can provide complementary strategies for the generation of isotopes for medical use and other applications. In this synergistic technique, unused “extra” isotopes created during the production of radioactive ion beams can be collected and purified for a variety of uses. Proof-of-principle experiments at the NSCL have shown the feasibility of this approach. The scale up in production yields with the installation of FRIB will allow for the harvesting of significant, useful quantities of various radioisotopes.

Contact: Alfredo Galindo-Uribarri, (865) 574-6124