Oak Ridge National Laboratory

Physics Division

Physics Division Seminars

Physics Division Seminars bring us speakers on a variety of physics related subjects. Usually these are held in the Building 6008 large Conference Room, at 3:00 pm on the chosen day, but times and locations may vary. For more information, contact our seminar chairman,

Alfredo Galindo-Uribarri
Tel (Office): (865) 574-6124  (FAX): (865) 574-1268

Fri., September 25, 2015, at 2:00 PM-3:00 PM (refreshments served at 1:40 PM)

High Specific Activity 153Sm by Post Irradiation Isotope Separation

Alan R. Ketring, University of Missouri, Columbia, MO
ORNL, Bldg. 6008 Large Conference Room

The isotope 153Sm has nuclear properties well suited for a variety of therapeutic applications; however, it is currently only available with low specific activity (radioactivity/mass) due to the method of production. Commercially quantities can be made by the 152Sm(n,γ)153Sm reaction in a nuclear reactor, but result in less than 2% of the 152Sm target material being converted to 153Sm, leading to a very specific activity. Since chemical processing methods cannot be used to perform isotopic separation, this means that >98% of the resultant pharmaceutical molecules are labeled with “cold” target atoms and are incapable of providing any radiation-induced therapeutic effect. The goals of this project were to introduce a new approach to the production of high specific activity (HSA) 153Sm utilizing electromagnetic isotope separation (EMIS), and to perform biodistribution and chemistry studies with such HSA 153Sm to test labeling capability with targeting molecules. Included in these studies was the successful development of a collection substrate that allows the efficient deposit and recovery of 153Sm; to this end, DLC (diamond-like carbon) foils were successfully employed.

Contact: Alfredo Galindo-Uribarri, (865) 574-6124